Organoids, Spheroids & Organs-on-Chips 2024
Date: Monday, 18 November 2024 - Wednesday, 20 November 2024
Location: The Hills Hotel -- Laguna Hills, California
Confirmed Speakers
Alice Soragni, Assistant Professor, University of California-Los Angeles
Holger Schmidt, Narinder Kapany Professor of Electrical Engineering, University of California-Santa Cruz
Mehdi Nikkhah, Associate Professor of Bioengineering, Arizona State University
Shuichi Takayama, Professor, Georgia Research Alliance Eminent Scholar, Georgia Institute of Technology
Alysson Muotri, Professor, Director of the Stem Cell Program, University of California-San Diego
Kevin Healy, Jan Fandrianto and Selfia Halim Distinguished Professorship in Engineering, University of California-Berkeley
Robert F. Halliwell, Professor of Neuroscience, School of Pharmacy, University of the Pacific
Steven C. George, Edward Teller Distinguished Professor and Chair, Department of Biomedical Engineering, University of California-Davis
Hervé Tiriac, Researcher, University of California-San Diego
Mandy Esch, Project Leader, National Institute of Standards and Technology (NIST)
Roger Kamm, Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Massachusetts Institute of Technology (MIT)
Organoids, Spheroids & Organs-on-Chips 2024
SelectBIO Organoids, Spheroids and Organs-on-Chips 2024 Conference focuses on an important and expanding field wherein cells are being assembled using Microfluidics and Lab-on-a-Chip technologies in a functionally-relevant manner. These clusters of "assembled cells" have functional significance and can mimic in vivo organ structure.
Liver cells assembled on-board chips in a physiologically-relevant architecture using microfluidics can, for instance, be utilized for toxicity screening and the ability to assemble organ fragments ex vivo can provide an exquisite means to reconstruct biological processes (both physiological and pathological) "in a dish" or "on a chip." A number of chips such Lung-on-a-Chip, Brain-on-a-Chip, Gut-on-a-Chip, Marrow-on-a-Chip, Bone-on-a-Chip, Nerve-on-a-Chip amongst others have been built and will be presented and explored at this conference. We will also focus on "disease-on-a-chip", cancer-on-a-chip, immune system-on-a-chip.
Registered delegates will have full access to the co-located and concurrent conference tracks to mix-and-match presentations and maximize networking:
• Lab-on-a-Chip and Microfluidics: Techologies, Companies and Commercialization 2024
• Innovations in Flow Cytometry and Extracellular Vesicles (EVs) 2024
• Organoids, Spheroids and Organs-on-Chips 2024
There are ample opportunities for networking, partnering and business development and this ensures a very cost-effective conference trip.
Call for Papers and Posters
Call for Papers
If you would like to be considered for an oral presentation at this meeting, Submit an abstract for review now!
Oral Presentation Submission Deadline: 31 March 2024
Call for Posters
You can also present your research on a poster while attending the meeting. Submit an abstract for consideration now!
Poster Submission Deadline: 04 November 2024
Agenda Topics
- • Cancer-on-a-Chip
• Organ-on-a-Chip/Body-on-a-Chip Assembly using Microfluidics: Tools and Approaches
• Organoids-on-a-Chip
• Organoids: Latest Trends in Research Activities -- Construction and Applications
• Spheroids -- 3D Aggregates of Cells in Culture: Technologies and Applications
Sponsorship and Exhibition Opportunities
Jeff Fan
Exhibition Manager - SelectBIO
E-mail: Jeff@selectbioconferences.com
3 for 2 Offer on Delegate Registrations
SelectBIO are offering 3 Delegate Registrations for the price of 2 on all delegate passes. To take advantage of this offer, please contact us by email, phone or click the Contact Us button below. Looking for more than 3 Delegate Passes? Contact us for more information on our special rates for large groups.
Any questions or assistance during registration, please call us at: +1 (510) 857-4865 or e-mail us at: Contact SelectBIO
Gold Sponsors
Exhibitors
If you require any information about exhibiting or sponsoring at one of our events please contact Jeff Fan using the information below:
Jeff Fan
Exhibition Manager - SelectBIO
Email: Jeff@selectbioconferences.com
Why exhibit at a SelectBIO Conference?
Specialists: SelectBIO doesn't organize conferences in shipping, accountancy, textiles etc. – just drug discovery and the life sciences. Many of our staff have bioscience qualifications and many years of experience. So, we speak your language and understand your needs.
Superior Customer Service: Our sales team will take care of you with specialist advice and customized packages. We don’t forget you after you sign on the bottom line either as our customer service dept. will alert you to all the things you need to think about up to and during the event itself.
Organoids, Spheroids & Organs-on-Chips 2024 Venue
SelectBIO is delighted to host the Organoids and Spheroids 2024 Conference at The Hills Hotel in Laguna Hills, California.
The Hills Hotel
25205 La Paz Road
Laguna Hills, California 92653, USA
This hotel in Southern California is easily accessible from Los Angeles and San Diego via Interstate-5.
The nearest airport is: John Wayne Airport (SNA) - 13.7 miles from the hotel.
From Los Angeles International Airport (LAX) - the hotel is 52.9 miles.
The hotel is within a short drive of Disneyland and Legoland California, as well as Laguna Beach, Newport Beach, as well as shopping and dining at South Coast Plaza in Costa Mesa.
All conference sessions, exhibition as well as networking reception will be held in the Conference Center at The Hills Hotel.
SelectBIO has negotiated discounted hotel room pricing for conference attendees at The Hills Hotel.
To make your Hotel Reservations Online:
Click the Button Below to Open the Hotel Booking Website
This will provide a SelectBIO discounted rate for booking hotel at the conference venue hotel
For any hotel reservation-related issues, or if you need any help with hotel bookings, please contact:
Jeff Fan
Events Manager, SelectBIO
E-mail: Jeff@selectbioconferences.com
SelectBIO has NOT authorized ANY third party company to assist in hotel bookings or reservations for the conference. Please do NOT do business with any third party companies. If in doubt, please contact Jeff Fan immediately to clarify.
Register to this conference and also enjoy the following co-located events at no extra charge.
Training Courses
If you would like to submit a proposal for an oral or poster presentation at this meeting, please fill out the form below required for your submission.
Successful applicants will be provided with all necessary information.
Abstract Content:
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Written in English
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Written in the third person
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Include title, name(s) and affiliation(s) of the authors
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Between 100 - 200 words
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Suitable for direct publication in the proceedings pack and on the website
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Related to the subject of the conference
Agenda Topics
- • Cancer-on-a-Chip
• Organ-on-a-Chip/Body-on-a-Chip Assembly using Microfluidics: Tools and Approaches
• Organoids-on-a-Chip
• Organoids: Latest Trends in Research Activities -- Construction and Applications
• Spheroids -- 3D Aggregates of Cells in Culture: Technologies and Applications
Copyrights
The presenting author/person who submitted the abstract assumes full responsibility of the content of the abstract and we assume that all co-authors are aware of this content. Please note that your biography, summary and abstract may be used on this website and conference materials.
Alice Soragni Biographical Sketch
Alice Soragni, Assistant Professor, University of California-Los Angeles
Alice Soragni is an Assistant Professor in the Department of Orthopedic Surgery at UCLA and a member of the Jonsson Comprehensive Cancer Center. Originally from Italy, she received her PhD in Physical Chemistry from ETH Zürich and a postdoctoral fellowship with David Eisenberg (UCLA) before starting her independent lab in December 2016 at UCLA David Geffen School of Medicine.
We develop strategies to test drugs in 3D tumor organoid models in a fast, reliable, high-throughput, inexpensive manner. Requiring few tumor cells, we aim to extend our methods to test combination of chemotherapies or targeted therapies directly on primary tumors from patients' biopsies or surgical samples in order to personalize treatment. Our most current work is focused on sarcoma, ovarian cancer, neuroendocrine tumors as well as neurofibromas.
Alysson Muotri Biographical Sketch
Alysson Muotri, Professor, Director of the Stem Cell Program, University of California-San Diego
PhD in Genetics by University of Sao Paulo, Brazil. Postdoctoral Work at The Salk Instutitue with neural stem cells and neurogenesis. Professor at UC San Diego, Dept. Pediatrics and Molecular & Cellular Medicine.
Hervé Tiriac Biographical Sketch
Hervé Tiriac, Assistant Researcher, University of California-San Diego
Dr. Tiriac received his Ph.D. from UC San Diego studying pre-mRNA splicing and transcription with Dr. Tracy Johnson. Herve’s research focuses on developing systems for precision medicine that may be utilized in the fight against pancreatic cancer. Herve did his postdoctoral fellowship with David Tuveson at Cold Spring Harbor Laboratory where he collaborated with Hans Clevers to establish protocols for PDAC organoid generation and testing.
Holger Schmidt Biographical Sketch
Holger Schmidt, Narinder Kapany Professor of Electrical Engineering, University of California-Santa Cruz
Holger Schmidt received the Ph.D. degree in electrical and computer engineering from the University of California Santa Barbara and served as a Postdoctoral Fellow at M.I.T. He is currently the Narinder Kapany Chair of Optoelectronics and Distinguished Professor of Electrical and Computer Engineering at UC Santa Cruz. He directs the W.M. Keck Center for Nanoscale Optofluidics and has served as the Associate Dean for Research in the Baskin School of Engineering. His research interests cover a broad range in photonics and integrated optics, including optofluidic devices, nanopore sensors, nano-magneto-optics, spintronic devices, and ultrafast optics. He has authored more than 400 publications, several book chapters, and co-edited the CRC Handbook of Optofluidics. He is a Fellow of the National Academy of Inventors, the IEEE and the Optical Society of America. He received an NSF Career Award, a Keck Futures Nanotechnology Award, and the Engineering Achievement Award by the IEEE Photonics Society.
Mandy Esch Biographical Sketch
Mandy Esch, Project Leader, National Institute of Standards and Technology (NIST)
Mandy B. Esch is a project leader in the Microsystems and Nanotechnology Division of the National Institute of Standards and Technology. She received a Diploma (equivalent to the American M.S. degree) in Biology and a Dr. rer. nat. (equivalent to the American Ph.D. degree) in Biotechnology from the Julius Maximilians University in Würzburg, Germany. During her PhD research she developed paper-based microfluidics and microfluidic biosensors for the detection of pathogens. In 2001, Dr. Esch joined the Cornell Nanoscale Science and Technology Facility as life sciences liaison. In 2007, she joined the Department of Biomedical Engineering at Cornell University as a Postdoctoral Research Associate. While there, she developed patents for cell culture on a porous 3D surface and for a multi-organ microphysiological system (MPS). She was part of the team that in 2015 received the Lush Science Prize for designing multi-organ fluidic cell culture systems. From 2015 to 2016 Dr. Esch spent a year as Assistant Professor at Syracuse University (Department of Biomedical and Chemical Engineering), where she taught nanobiotechnology. In August 2016 Dr. Esch moved to NIST, where she is focusing on integrating sensors with tissues-on-chips and multi-organ microphysiological systems.
Mehdi Nikkhah Biographical Sketch
Mehdi Nikkhah, Associate Professor of Bioengineering, Arizona State University
Mehdi Nikkhah is currently an Associate Professor of Biomedical Engineering at Arizona State University (ASU). He completed his postdoctoral fellowship training at Harvard Medical School and Brigham and Women’s Hospital. He received his B.S. in mechanical engineering and M.S. degree in biomedical engineering from Tehran Polytechnic University, followed by a Ph.D. in mechanical engineering from Virginia Tech. His research focuses on integrating micro- and nano-scale technologies, innovative biomaterials, and single-cell resolution analysis to better understand the mechanisms of human disease progression and to develop regenerative medicine strategies for treating organ/tissue failure. Dr. Nikkhah has published more than 80 journal articles (over 11,000 citations, H-index of 48), 8 book chapters, and 100 peer-reviewed conference papers, and holds 10 US patents and invention disclosures. His translational research has been supported by multiple federal, state, and local agencies, including NSF, NIH (R01, R21) and Arizona Biomedical Research Consortium. He has received numerous recognitions and prestigious awards throughout his career, including induction into the American Institute for Medical and Biological Engineering (AIMBE) as a Fellow, induction into the National Academy of Inventors (NAI) as a Senior Member, NSF CAREER Award, BMES-CMBE Young Innovator Award, Flinn Foundation Award, ASU Biomedical Engineering Outstanding Assistant Professor Award, and others. Along with his research endeavors, Dr. Nikkhah is very passionate about educating the next generation of students and scholars, with specific attention to minority and underrepresented groups in science and engineering. He has trained more than 75 trainees, including postdoctoral fellows, PhD/MS students, and undergraduate researchers from diverse backgrounds, in his lab.
Robert Halliwell Biographical Sketch
Robert F. Halliwell, Professor Neuroscience, School of Pharmacy, University of the Pacific
Robert F. Halliwell completed postgraduate training in neurological science at University College London, in pharmacology at Ninewells Hospital & Medical School, University of Dundee and a Post-Doctoral Fellowship in Neuroscience at the University of California, Irvine. I previously held a lectureship in Neuroscience at the University of Durham, England and I am currently Professor in Neuroscience in the School of Pharmacy, University of the Pacific. I contribute to Schools of Neuroscience in Africa for IBRO; I am a member of the Medical Ethics Committee at St Joseph’s Medical Center, Stockton, CA, and an Advisor on Mental Health for the Wellness Center of San Joaquin County. My laboratory is addressing the properties and value of neurons derived from a variety of human stem cells for studies in neuropharmacology and neurotoxicology; I have also published work in the history of medicine.
Roger Kamm Biographical Sketch
Roger Kamm, Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering, Massachusetts Institute of Technology (MIT)
Professor Kamm is currently the Cecil and Ida Green Distinguished Professor of Biological and Mechanical Engineering at MIT, where he has served on the faculty since 1978. Kamm has long been instrumental in developing research activities at the interface of biology and mechanics, formerly in cell and molecular mechanics, and now in engineered living systems. Current interests are in developing models of healthy and diseased organ function using microfluidic technologies, with a focus on vascularization. Kamm has fostered biomechanics as Chair of the US National Committee on Biomechanics (2006-2009) and of the World Council on Biomechanics (2006-2010). Kamm currently directs the NSF Science and Technology Center on Emergent Behaviors of Integrated Cellular Systems. He is the 2010 recipient of the ASME Lissner Medal (American Society of Mechanical Engineering) and the 2015 recipient of the Huiskes Medal (European Society of Biomechanics), both for lifetime achievements, and is the inaugural recipient of the ASME Nerem Medal for mentoring and education. He was elected to the National Academy of Medicine in 2010. Kamm is co-founder of two companies, Cardiovascular Technologies and AIM Biotech, a manufacturer of microfluidic systems for 3D culture.
Shuichi Takayama Biographical Sketch
Shuichi Takayama, Professor, Georgia Research Alliance Eminent Scholar, Georgia Institute of Technology
Prof. Shuichi Takayama’s research interests started with bioorganic synthesis at the University of Tokyo and Scripps Research Institute. Subsequently he pursued postdoctoral studies in bioengineered microsystems at Harvard University as a Leukemia and Lymphoma Society Fellow. He spent 17 years at the University of Michigan in the Biomedical Engineering Department and Macromolecular Science and Engineering Program, then moved to the Wallace H. Coulter Department of Biomedical Engineering at the Georgia Institute of Technology and Emory School of Medicine in the summer of 2017. He is an associate editor of Integrative Biology and recipient of the Pioneers of Miniaturization Prize.
Steve George Biographical Sketch
Steven C. George, Edward Teller Distinguished Professor and Chair, Department of Biomedical Engineering, University of California-Davis
Steven C. George, M.D., Ph.D. is a Professor of Biomedical Engineering at the University of California, Davis. He received his bachelors degree in chemical engineering in 1987 from Northwestern University, M.D. from the University of Missouri School of Medicine in 1991, and Ph.D. from the University of Washington in chemical engineering in 1995. He was on the faculty at the University of California, Irvine for 19 years (1995-2014) where he pursued a range of research interests including pulmonary gas exchange, lung mechanics, vascularizing engineered tissues, and microphysiological systems. The NIH FIRST award in 1998 and the CAREER and Presidential Early Career Award for Scientists and Engineers (PECASE) from the National Science Foundation in 1999 have previously recognized his work. While at UCI, he served as the William J. Link Professor and founding Chair of the Department of Biomedical Engineering (2002-2009), the Director of the Edwards Lifesciences Center for Advanced Cardiovascular Technology (2009-2014), and was the PI on a T32 predoctoral training grant from the National Heart Lung and Blood Institute. In 2014 he transitioned to become the Elvera and William Stuckenberg Professor and Chair of Biomedical Engineering at Washington University in St. Louis, and in 2017 moved to the UC Davis. He was elected a fellow in the American Institute of Medical and Biological Engineering (AIMBE) in 2007, a fellow of the Biomedical Engineering Society in 2017, has published more than 140 peer-reviewed manuscripts, and co-founded two early start-up companies. His work is currently funded by grants from the NIH that focus on creating tissue engineered models of the cardiac, pancreas, bone marrow, and cancer microenvironments using induced pluripotent stem cell and microfabrication technology.
09:00
18 November 2024
Slate Room
Steve Soper, Foundation Distinguished Professor; Director, Center of BioModular Multi-scale System for Precision Medicine, Adjunct Professor, Ulsan National Institute of Science & Technology, The University of Kansas
Pre-Conference Training Course from 09:00-11:00
Microfluidics and Nanofluidics for Diagnostic Tests
[Separate Registration Required to Attend this Pre-Conference Training Course]
11:00
18 November 2024
Slate Room
Leanna Levine, Founder & CEO, ALine, Inc. United States of America
Pre-Conference Training Course from 11:00-13:00
Microfluidic Product Development
[Separate Registration Required to Attend this Pre-Conference Training Course]
This training course will explore the translation of science and nascent engineering programs into a well-structured product development program to address Reduction to Practice or proof of concept; Human factors engineering – what is it and why it matters; Design Control and Risk Control Roadmap for Development; Design for Manufacture and Assembly; Scale -up progression and manufacturing methods.
**A Must-Attend for Companies Embarking on Microfluidic Product Development**
13:00
18 November 2024
Conference Entrance
Conference Registration, Materials Pick-Up and Networking in the Exhibit Hall
13:30
18 November 2024
Plenary Ballroom
Session Title:
Lab-on-a-Chip and Microfluidics World Congress 2024
Opening Plenary Session
13:45
18 November 2024
Plenary Ballroom
Welcome and Introduction to the Lab-on-a-Chip and Microfluidics World Congress 2024 by the Chairs: Professor Dino Di Carlo and Dr. Leanna Levine
2024 Conference Focus and Themes Highlighted Over the 3-Day Event
14:00
18 November 2024
Plenary Ballroom
View Agenda of Conference Plenary Session on the Agenda Page of the Lab-on-a-Chip and Microfluidics 2024 Track
18:45
18 November 2024
Exhibit Hall
Networking Reception in the Exhibit Hall with Beer, Wine and Dinner.
Network with Colleagues, Engage with the Exhibitors and View Posters.
20:15
18 November 2024
Exhibit Hall
Close of Day 1 of the Conference
20:30
18 November 2024
Slate Room
Noah Malmstadt, Professor of Chemical Engineering and Materials Science, University of Southern California, United States of America
3D-Printing of Microfluidics Training Course
[Separate Registration Required to Attend this Training Course]
07:30
19 November 2024
Exhibit Hall
Morning Coffee, Continental Breakfast and Networking in the Exhibit Hall
08:58
19 November 2024
Ballroom A
Session Title: Emerging Themes and Trends in Lab-on-a-Chip and Microfluidics 2024
09:00
19 November 2024
Ballroom A
For Presentations from 09:00 - 10:30, please see Lab-on-a-Chip Track Agenda
10:55
19 November 2024
Ballroom A
Presentations Focusing on Organoids in this Session
11:00
19 November 2024
Ballroom A
Holger Schmidt, Distinguished Professor of Electrical and Computer Engineering, Narinder Singh Kapany Chair of Optoelectronics, Director, W.M. Keck Center for Nanoscale Optofluidics, University of California-Santa Cruz, United States of America
Lab-on-Chip Devices For Analysis of Extracellular Vesicles and Their Contents From Cerebral Organoid Tissue
Cultured organoids have emerged as important test beds for studying cell development and disease. Sub-micron sized extracellular vesicles (EVs), including exosomes, secreted by these organoids provide an ideal opportunity for assessing and continuously monitoring organoid status on the molecular level. I will describe the development of integrated lab-on-chip devices for real-time analysis of EVs produced in a custom 3D cerebral organoid tissue culture platform. This includes the detection of individual exosomes as well as their molecular biomarker cargo using single particle fluorescence and trapping-assisted nanopore sensing. I will also discuss the direct incorporation of this electro-optofluidic lab-on-chip within the tissue culture platform.
11:30
19 November 2024
Ballroom A
Mehdi Nikkhah, Associate Professor of Bioengineering, Arizona State University, United States of America
Integrating Tissue-on-a-Chip Systems with Single-Cell Analysis to Study Disease Progression and Test Therapeutics
Ex vivo three-dimensional (3D) organotypic tissue-on-a-chip models have become essential tools in biomedical and preclinical research. These technologies provide a deeper understanding of complex human diseases, effectively addressing the limitations of traditional animal models. Tissue-on-a-chip systems have also significantly accelerated drug development by creating scalable, high-throughput platforms for efficiently evaluating the effectiveness of various drugs and compounds. In this seminar, Dr. Nikkhah will present his lab's multidisciplinary research, which integrates microfluidic technologies, advanced biomaterials, and single-cell analysis to engineer the next generation of physiologically relevant tissue-on-a-chip platforms for disease modeling and drug testing. The seminar will particularly emphasize their innovative work in designing complex diseased landscapes, such as the tumor microenvironment (TME), to study the early stages of cancer progression, particularly during invasion and metastasis. Additionally, this seminar will also discuss how disease-on-a-chip systems facilitate novel target and drug discoveries for advanced therapeutics.
12:00
19 November 2024
Ballroom A
Alysson Muotri, Professor, Director of the Stem Cell Program, University of California-San Diego, United States of America
Applications of Human Brain Organogenesis
Structural and transcriptional changes during early brain maturation follow fixed developmental programs defined by genetics. However, whether this is true for functional network activity remains unknown, primarily due to experimental inaccessibility of the initial stages of the living human brain. We developed cortical organoids that spontaneously display periodic and regular oscillatory network events that are dependent on glutamatergic and GABAergic signaling. These nested oscillations exhibit cross-frequency coupling, proposed to coordinate neuronal computation and communication. As evidence of potential network maturation, oscillatory activity subsequently transitioned to more spatiotemporally irregular patterns, capturing features observed in preterm human electroencephalography (EEG). These results show that the development of structured network activity in the human neocortex may follow stable genetic programming, even in the absence of external or subcortical inputs. Our approach provides novel opportunities for investigating and manipulating the role of network activity in the developing human cortex. Applications for neurodevelopmental disorders, brain evolution and space exploration will be discussed.
12:30
19 November 2024
Exhibit Hall
Networking Buffet Luncheon -- Network with Exhibitors and Colleagues, View Posters
13:20
19 November 2024
Ballroom A
Session Title: Organoids and Organs-on-chips -- Utilizing Microfluidics for Harvesting Biological Insights
13:30
19 November 2024
Ballroom A
Shuichi Takayama, Professor, Georgia Research Alliance Eminent Scholar, Georgia Institute of Technology, United States of America
Organoids with Reversed Biopolarity (ORBs): SARS-CoV-2 Drug Testing and Breast Cancer Progression
This presentation will describe production of sub-millimeter diameter, consistent size and shape, lung, kidney, and mammary organoids that have an inverted, apical-out geometry. These Organoids with Reversed Biopolarity (ORBs) are used in 384 well plates in a single-organoid-per-well format to test drugs and disease physiology. The airway ORBs are infected with high yields with multiple SARS-CoV-2 strains with Omicron variant showing highest viral replication and Delta giving the most inflammatory response. The ORBs also predict anti-viral drug efficacy correctly where conventional 2D cultures give false signals. Early-stage breast cancer progression model studies will also be discussed.
14:00
19 November 2024
Ballroom A
Alice Soragni, Assistant Professor, University of California-Los Angeles, United States of America
Leveraging Patient-derived Tumor Organoids For Precision Medicine
Patient-derived tumor organoids (PDTOs) are representative of the histopathology and physiological behavior of tumors. They are clinically relevant, tractable ex vivo models that can be quickly established from tumor biopsies and surgical samples. There is increasing interest in leveraging tumor organoids for drug development and personalized medicine applications for their ability to maintain principal features of the tumor they originate from, including drug response. PDTOs are particularly important to model rare tumors which often completely lack experimental models. We routinely establish organoids from a spectrum of tumors, including rare ovarian and peritoneal cancers (Phan et al, Communications Biology, 2019), benign tumors such as cutaneous neurofibromas (Nguyen et al, Cell Reports Methods, 2024), indolent bone cancers (Al Shihabi et al, Science Advances, 2022) and aggressive sarcomas (Al Shihabi et al, in press, 2024). We have developed a unique organoid screening platform that uses a modified geometry to seed or bioprint cells in a robust, high throughput and automation-compatible format that bypasses the need for any cell sorting, passaging or in vitro expansion. Our short screening timeline, with results available within one week from surgery, is compatible with therapeutic decision making. Overall, we have been able to identify unique drug responses to both fast and slow-growing cancers, including for tumors that are recalcitrant or impossible to grow as patient-derived xenografts. In a pilot study of PDTOs established from over 120 sarcomas, a family of rare tumors arising from bone or soft tissue, we demonstrated how PDTO drug screening provides sensitivity information that correlates with clinical features yielding actionable information for treatment guidance (Al Shihabi et al, in press, 2024). Importantly, sarcoma organoid responses complemented genetic sequencing and mirrored patient outcomes, leading to the launch of a clinical trial to test PDTO use in osteosarcoma (An Organoid-based Functional Precision Medicine Trial in Osteosarcoma: PREMOST, NCT06064682).
14:30
19 November 2024
Ballroom A
Mandy Esch, Project Leader, National Institute of Standards and Technology (NIST), United States of America
Development of Pumpless Single-Organ and Multi-Organ MPS
Single and multi-organ microphysiologic systems (MPS) can be used to detect secondary drug toxicities stemming from drug metabolites. Here we describe how to design and prototype such systems to replicate key aspects of the human body that influence the concentration of drug metabolites within the system. Using 3D printing we have prototyped and tested several microfluidic MPS that operate with liver and heart tissues and that can recirculate near-physiological amounts of cell culture medium. We have also developed several devices that recirculate small amounts of cell culture medium in a way that makes it feasible to culture mechano-sensitive cells such as HUVEC or GI tract epithelial cells within the system. The talk given here is a summary of our efforts in this area.
15:00
19 November 2024
Exhibit Hall
Mid-Afternoon Coffee Break and Networking in the Exhibit Hall
15:25
19 November 2024
Ballroom A
Please view Agenda for the Second Half of the Afternoon in the Lab-on-a-Chip Track Agenda
18:30
19 November 2024
Exhibit Hall
Networking Reception with Beer, Wine and Dinner in the Exhibit Hall -- Network with Exhibitors, Colleagues and View Posters
20:15
19 November 2024
Exhibit Hall
Close of Day 2 Main Conference Programming
20:30
19 November 2024
Slate Room
Shuichi Takayama, Professor, Georgia Research Alliance Eminent Scholar, and Price Gilbert, Jr. Chair in Regenerative Engineering and Medicine, Georgia Institute of Technology & Emory University School of Medicine, United States of America
Introduction to Microfluidics Training Course
[Separate Registration Required to Attend this Training Course]
07:30
20 November 2024
Exhibit Hall
Morning Coffee, Continental Breakfast and Networking in the Exhibit Hall
08:00
20 November 2024
Industry Breakout Round Tables: Each Round-Table Moderated by an Industry Participant -- Delegates Engage with Moderator and Each Other to Discuss Commercialization Themes
Moderators are:
David Weitz, Harvard – Microfluidics
Roger Kamm, MIT – Organs-on-Chips
Greg Cooksey, NIST – Flow Cytometry
09:00
20 November 2024
Ballroom B
Session Title: Continuing Coverage of Organoids
09:30
20 November 2024
Ballroom B
Robert Halliwell, Professor of Neuroscience, University of The Pacific, United States of America
Neurons from Human Stem Cells in 2D and 3D Culture for the Discovery of New Antiseizure Agents
Somatic tissues derived from human stem cells offer significant advantages over animal models for drug studies and disease modeling. For over 20 years, my lab has been addressing the neuropharmacological and neurophysiological properties of human stem cell derived neurons in 2D and, more recently, in 3D culture. This presentation will cover the challenges and advantages in combining stem cell created neuroglial cells, maintained in ultra-long-term culture, with multi-electrode array technology, to advance the discovery of novel antiseizure agents for epilepsy. Specifically, I will present recent data demonstrating that human neuroglia cell networks are able to detect the antiseizure properties of diverse antiepileptic drugs with high sensitivity, specificity and reliability. I will also present one of our recent studies showing that fenamates, a well-established class of NSAID, that are also subunit-selective potentiators of the GABAA receptor (the major inhibitory receptor in the brain) have potent antiseizure properties. These observations provide new evidence for a novel therapeutic approach to the treatment of epilepsy, and we are exploring these well-established NSAIDs for drug repurposing. Overall, our data, and that emerging from other labs, demonstrate the power of stem cell derived neural circuits, supported by glia to identify new and novel agents for complex, difficult-to-treat, neuropsychiatric disorders.
10:00
20 November 2024
Ballroom B
For Remaining Talks in this Session, Please see Details Under Flow Cytometry and EVs Agenda
13:00
20 November 2024
Exhibit Hall
Networking Buffet Luncheon in the Exhibit Hall -- Network with Exhibitors, Colleagues and View Posters
15:00
20 November 2024
Ballroom A
Poster Awards
3 Cash Awards Sponsored by the RSC and Lab-on-a-Chip Journal + Raffle for iPad Drawing